The use of nanoparticles NP in diagnosis and treatment of many human diseases, including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the uptake efficiency significantly limit their use in clinical practice. The physico-chemical properties of NPs including surface composition, superficial charge, size and shape are considered the key factors that affect the biocompatibility and uptake efficiency of these nanoplatforms. Thanks to the possibility of modifying physico-chemical properties of NPs, it is possible to improve their biocompatibility and uptake efficiency through the functionalization of the NP surface.

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The synthesis of the asymmetric ligand 3-phenyl pyridinyl -1H-pyrazolamine L1 and its single-crystal X-ray structure are reported. Upon complexation with ZnCl2, L1 engages in both primary cation and secondary anion coordination via hydrogen bonding, and the complex exhibits a room-to-low-temperature single crystal-to-crystal phase transition. The ZnCl2 complex becomes a birefringent fluid mixed with crystalline domains at high temperatures, as detected by polarized optical microscopy.


The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. A high biocompatibility and efficient delivery properties of nanoparticles NPs were recognized as important targets toward multipurpose efficient nanomedical solution since ideal carrier properties include safety and optimal bioavailability Naahidi et al. Primary requirements for NPs include stability, nontoxicity, non-immunogenicity and targeting capability to a specific site. Most of these properties can be achieved and tuned via clever manipulation of their shape, size and surface chemistry, which are responsible for cellular internalization, half-life in blood and immune response Albanese et al.